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Familial Hypercholesterolemia       Article     History   Tree Map
  Encyclopedia of Keywords > Apolipoprotein > Familial Hypercholesterolemia   Michael Charnine

Keywords and Sections
MORTALITY
INCIDENCE
COMPARISON
PATIENT
INTRAFAMILIAL VARIABILITY
HETEROZYGOUS
CARDIOVASCULAR RISK
CELLS
SHORT-TERM EFFICACY
WATANABE HERITABLE HYPERLIPIDEMIC RABBIT
FAMILIAL LOW HORMONE PRODUCTION
SIMVASTATIN TREATMENT
HOMOZYGOUS FORM
BROWN MS
STATIN THERAPY
SPECTRUM
USEFUL
PERSON
TREAT
THERAPY
COMPOSITION
CORONARY
MANAGEMENT
MEN
INFLUENCE
DETECTION
GENETIC
FAMILIES
GENES
CLINICALLY
EFFECTS
STATINS
DEFECT
LOW DENSITY LIPOPROTEIN
FAMILY HISTORY
HIGH CHOLESTEROL LEVELS
LDL CHOLESTEROL
COMMON
SAFETY
INHERITED
GENETIC DISORDER
LEVELS
HIGH CHOLESTEROL
RISK
CARDIOVASCULAR DISEASE
HEART ATTACK
Review of Short Phrases and Links

    This Review contains major "Familial Hypercholesterolemia"- related terms, short phrases and links grouped together in the form of Encyclopedia article.

Definitions

  1. Familial hypercholesterolemia is a disorder of high LDL ("bad") cholesterol that is passed down through families, which means it is inherited. (Web site)
  2. Familial hypercholesterolemia is a genetic condition that results in markedly elevated LDL-C levels beginning at birth and heart attacks at an early age. (Web site)
  3. Familial hypercholesterolemia is a rare genetic disorder that can occur in families, wherein those affected cannot properly metabolise cholesterol. (Web site)
  4. Familial hypercholesterolemia is an autosomal-dominant inherited disorder caused by mutations in the low-density lipoprotein (LDL) receptor gene.
  5. Familial hypercholesterolemia is a disease that is usually inherited from one parent in an autosomal dominant manner.

Mortality

  1. Mortality in treated heterozygous familial hypercholesterolemia: implications for patient management. (Web site)

Incidence

  1. The incidence of familial hypercholesterolemia is seven out of 1,000 people. (Web site)

Comparison

  1. Comparison of ezetimibe plus simvastatin versus simvastatin monotherapy on atherosclerosis progression in familial hypercholesterolemia. (Web site)

Patient

  1. Coronary disease can be averted in one patient for every three identified with familial hypercholesterolemia.

Intrafamilial Variability

  1. Intrafamilial variability in the clinical expression of familial hypercholesterolemia: importance of risk factor determination for genetic counselling. (Web site)

Heterozygous

  1. Comparison of rosuvastatin versus atorvastatin in patients with heterozygous familial hypercholesterolemia. (Web site)
  2. Characteristic cardiovascular manifestation in homozygous and heterozygous familial hypercholesterolemia. (Web site)
  3. Aortic stiffness in young patients with heterozygous familial hypercholesterolemia.

Cardiovascular Risk

  1. The type of LDLR gene mutation predicts cardiovascular risk in children with familial hypercholesterolemia. (Web site)

Cells

  1. Comparison of cells from a normal subject and from a patient with homozygous familial hypercholesterolemia.

Short-Term Efficacy

  1. Short-term efficacy and safety of pravastatin in 72 children with familial hypercholesterolemia [published correction appears in Pediatr Res. (Web site)

Watanabe Heritable Hyperlipidemic Rabbit

  1. Regulation of apolipoprotein B secretion in hepatocytes from Watanabe heritable hyperlipidemic rabbit, an animal model for familial hypercholesterolemia. (Web site)

Familial Low Hormone Production

  1. Our clinical experience shows that familial hypercholesterolemia could be considered familial low hormone production instead of familial high cholesterol.

Simvastatin Treatment

  1. Familial hypercholesterolemia with null mutations showed a poor response to simvastatin treatment. (Web site)

Homozygous Form

  1. High affinity binding of similar magnitude was not observed in cells from five unrelated subjects with the homozygous form of familial hypercholesterolemia.
  2. Parke-Davis contacted two South African doctors who were treating a group of young patients with the homozygous form of familial hypercholesterolemia.

Brown Ms

  1. Goldstein JL, Brown MS. The LDL receptor locus and the genetics of familial hypercholesterolemia.

Statin Therapy

  1. Raised serum levels of soluble CD40 ligand in patients with familial hypercholesterolemia: downregulatory effect of statin therapy.

Spectrum

  1. Spectrum of LDL receptor gene mutations in Denmark: implications for molecular diagnostic strategy in heterozygous familial hypercholesterolemia. (Web site)

Useful

  1. Studies suggest, for example, that plasmapheresis is particularly useful for patients with familial hypercholesterolemia.

Person

  1. A person with familial hypercholesterolemia inherits an abnormal gene for the docking site from one or both parents. (Web site)
  2. Rarely, a person with familial hypercholesterolemia is born with two mutated copies of the LDLR gene.

Treat

  1. This is called familial hypercholesterolemia and can be difficult to treat.

Therapy

  1. A potentially effective therapy for homozygous familial hypercholesterolemia would be to reduce LDL production.

Composition

  1. Composition and distribution of low density lipoprotein fractions in hyperapobetalipoproteinemia with normolipidemia, and familial hypercholesterolemia. (Web site)

Coronary

  1. Coronary flow reserve is impaired in young men with familial hypercholesterolemia.

Management

  1. The management of patients with familial hypercholesterolemia and related disorders are also discussed separately. (Web site)

Men

  1. CONTEXT: Heterozygous familial hypercholesterolemia (HeFH) is a common disorder associated with early coronary artery disease, especially in men. (Web site)

Influence

  1. Influence of diets containing cow's milk or soy protein beverage on plasma lipids in children with familial hypercholesterolemia. (Web site)
  2. Influence of apo E polymorphism on the response to simvastatin treatment in patients with heterozygous familial hypercholesterolemia. (Web site)

Detection

  1. Detection of mutations and large rearrangements of the low-density lipoprotein receptor gene in Taiwanese patients with familial hypercholesterolemia.
  2. Patients' attitudes toward detection of heterozygous familial hypercholesterolemia. (Web site)

Genetic

  1. Genetic and environmental factors affecting the incidence of coronary artery disease in heterozygous familial hypercholesterolemia.

Families

  1. Families with a history of familial hypercholesterolemia may benefit from counseling, especially if both parents are affected.

Genes

  1. Children who inherit two genes can have accelerated and graver versions of the illness, called homozygous familial hypercholesterolemia.

Clinically

  1. Familial defective apolipoprotein B-100 is clinically indistinguishable from familial hypercholesterolemia.
  2. Frequency of the R3500Q mutation of the apolipoprotein B-100 gene in a sample screened clinically for familial hypercholesterolemia in Hungary.

Effects

  1. Effects of a soy-protein beverage on plasma lipoproteins in children with familial hypercholesterolemia.
  2. Effects of oral folic acid supplementation on endothelial function in familial hypercholesterolemia.
  3. Effects of plant stanol and sterol esters on serum phytosterols in a family with familial hypercholesterolemia including a homozygous subject. (Web site)

Statins

  1. Statins are the first choice treatment for all patients with heterozygous familial hypercholesterolemia.
  2. What this means to you: Taking statins appears to help kids with familial hypercholesterolemia.

Defect

  1. These results indicate that patients with familial hypercholesterolemia have a defect in the interaction of hepatic membranes with low density lipoproteins. (Web site)

Low Density Lipoprotein

  1. LDL apheresis - removal of low density lipoprotein in patients with familial hypercholesterolemia. (Web site)
  2. Oxidative structural modifications of low density lipoprotein in homozygous familial hypercholesterolemia.

Family History

  1. Family history and cardiovascular risk in familial hypercholesterolemia: data in more than 1000 children. (Web site)

High Cholesterol Levels

  1. Familial hypercholesterolemia is an inherited disease that causes high cholesterol levels. (Web site)
  2. Rarely, high cholesterol levels develop because of a condition that runs in the family called a lipid disorder, or familial hypercholesterolemia.

Ldl Cholesterol

  1. Plant sterol ester-enriched spread lowers plasma total and LDL cholesterol in children with familial hypercholesterolemia.

Common

  1. The most common cause of inherited high cholesterol is a condition known as familial hypercholesterolemia, which results from mutations in the LDLR gene.

Safety

  1. The safety and efficacy of doses above 40 mg daily have not been studied in children with heterozygous familial hypercholesterolemia. (Web site)
  2. Safety and efficacy not established in children younger than 10 yr of age or for indications other than heterozygous familial hypercholesterolemia. (Web site)
  3. Short-term efficacy and safety of pravastatin in 72 children with familial hypercholesterolemia. (Web site)

Inherited

  1. Familial hypercholesterolemia is inherited in families in an autosomal dominant manner. (Web site)

Genetic Disorder

  1. Familial hypercholesterolemia is a genetic disorder caused by a defect on chromosome 19. (Web site)

Levels

  1. Relationship between cholesteryl ester transfer protein levels and risk factor profile in patients with familial hypercholesterolemia. (Web site)

High Cholesterol

  1. Those with familial hypercholesterolemia are more likely to have a family history of high cholesterol and heart disease at a younger age than normal. (Web site)
  2. Mutations in the LDLR gene cause an inherited form of high cholesterol called familial hypercholesterolemia.

Risk

  1. Risk of death varies among patients with familial hypercholesterolemia. (Web site)
  2. The risk of brain infarction in these subjects with familial hypercholesterolemia was at least 20 times higher than in the general population. (Web site)

Cardiovascular Disease

  1. Heterozygous familial hypercholesterolemia: an underrecognized cause of early cardiovascular disease.
  2. In medicine, familial hypercholesterolemia is a rare disease characterised by very high LDL cholesterol and early cardiovascular disease running in families.
  3. Despite this general statement, data regarding the incidence of cardiovascular disease in young women with familial hypercholesterolemia are lacking. (Web site)

Heart Attack

  1. Men with familial hypercholesterolemia typically have a heart attack in their 40s to 50s. (Web site)

Categories

  1. Apolipoprotein
  2. Medicine > Drugs > Statins > Lovastatin
  3. Ldl
  4. Simvastatin
  5. Medicine > Drugs > Statins > Pravastatin

Related Keywords

    * Additional Therapy * Apolipoprotein * Atorvastatin * Children * Cholesterol * Cholesterol Metabolism * Coronary Artery Disease * Coronary Heart Disease * Diagnosis * Effect * Efficacy * Ezetimibe * Gene * Heart Attacks * Heterozygous Familial Hypercholesterolemia * Homozygous * Homozygous Familial Hypercholesterolemia * Hypercholesterolemia * Ldl * Ldl Receptor * Ldl Receptor Gene * Lipoproteins * Long-Term Safety * Lovastatin * Miettinen Ta * Molecular Basis * Mutations * Patients * Pravastatin * Premature Atherosclerosis * Probucol * Severe * Simvastatin * Study * Treatment * Xanthomas
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  Short phrases about "Familial Hypercholesterolemia"
  Originally created: May 04, 2008.
  Links checked: May 08, 2013.
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