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This Review contains major "Lovastatin"- related terms, short phrases and links grouped together in the form of Encyclopedia article.
- Lovastatin is a lactone which is readily hydrolyzed in vivo to the corresponding (beta)-hydroxyacid, a potent inhibitor of HMG-CoA reductase.
- Lovastatin is a cholesterol-lowering medication that blocks the production of cholesterol (a type of fat) in the body.
- Lovastatin is a cholesterol lowering agent isolated from a strain of Aspergillus terreus.
- Lovastatin is a specific inhibitor of HMG-CoA reductase, the enzyme which catalyzes the conversion of HMG-CoA to mevalonate.
- Lovastatin is a naturally occurring drug found in food such as oyster mushrooms[ 1] and red yeast rice[ 2].
- Apolipoprotein B concentration falls substantially during treatment with lovastatin.
- Estrogen-replacement therapy appeared to have no effect on either the efficacy or safety profile of lovastatin.
- Later, the presence of lovastatin was detected in a submerged culture of three higher Basidiomycetes species: Pleurotus ostreatus, P. saca and P. sapidus.
- Lovastatin is comprised of 2 polyketide chains derived from acetate that are 8- and 4- carbons long coupled in head to tail fashion.
- Low-dose lovastatin safely lowers cholesterol after cardiac transplantation.
- B. Testing of lovastatin Lovastatin content in the submerged mycelium was determined according to the method described in Example 1.
- Researchers aren't sure if the cholesterol-lowering effect of red yeast rice was due to the presence of lovastatin or other compounds in red yeast rice.
- Both lovastatin and its b-hydroxyacid metabolite are highly bound (95%) to human plasma proteins.
- Both lovastatin and its (beta)-hydroxyacid metabolite are highly bound (95%) to human plasma proteins.
- Efficacy of extended-release niacin with lovastatin for hypercholesterolemia: assessing all reasonable doses with innovative surface graph analysis.
- Advicor is a combination product containing both extended-release niacin and lovastatin (Mevacor).
- Therefore, the combined use of lovastatin with other fibrates should generally be avoided.
- Rice fermented with red yeast contains several types of mevinic acids, including monacolin K, which is identical to lovastatin.
- Cholestin is an extract from RYR containing a special strain of yeast which produces monacolin K (lovastatin) [ 7].
- The structure of Lovastatin was determined to be different from that of mevastatin by the presence of a 6 alphamethyl group in the hexahydronaphthalene ring.
- All actions at purchase Mevacor, Lestric, Lovastatin are executed with our safe operational server.
- The frequency of patients reporting improvement on quality of life domains was greater in the policosanol than in the lovastatin group.
- After eight weeks of therapy, LDL-cholesterol was reduced 24% in the policosanol groups, 22% in the lovastatin group and 15% with simvastatin.
- In the lovastatin group there was a significant reduction in the number of patients with major cardiovascular events relative to the placebo group (5 vs.
- Although lovastatin tablets 10 mg are available in the marketplace, MEVACOR is no longer marketed in the 10 mg strength.
- Take lovastatin tablets by mouth.
- The long-term efficacy of lovastatin therapy in childhood to reduce morbidity and mortality in adulthood has not been established.
- Lovastatin therapy should be discontinued immediately if myopathy is diagnosed or suspected.
- Not all the effects listed below have necessarily been associated with lovastatin therapy.
- The increase in AUC for lovastatin and lovastatin acid is presumably due, in part, to inhibition of CYP3A4.
- We conclude that lovastatin can induce apoptosis in BPH stromal cells in vitro, and this is not affected by androgen withdrawal or stimulation.
- One of these, monacolin K, has the same chemical makeup as lovastatin, a prescription drug that lowers cholesterol.
- Comparative efficacy study of atorvastatin vs simvastatin, pravastatin, lovastatin and placebo in type 2 diabetic patients with hypercholesterolaemia.
- Lovastatin reduces cholesterol production by the liver and induces some changes in cholesterol transport and disposition in the blood and tissues.
- Changes in ICD and ACD were significantly larger in the policosanol than in the lovastatin group (p < 0.01).
- Transient, mildly elevated creatine phosphokinase levels are commonly seen in lovastatin treated patients.
- In large, comparative trials atorvastatin produced greater reductions in TC, LDL-C, apo B, and TGs than lovastatin, pravastatin, or simvastatin.
- Consequently, lovastatin therapy could also result in a lowering of cellular CoQ levels.
- No lovastatin was detected in the culture broth filtrate samples after separation from the mycelium.
- B. Testing of lovastatin The incubated broth was filtered through a filter cloth to remove the mycelium and washed twice with distilled water.
- Tell your doctor or dentist that you take Lovastatin before you receive any medical or dental care, emergency care, or surgery.
- Check with your doctor before drinking alcohol while you are taking Lovastatin.
- The culture of these strains to produce lovastatin is carried out in aqueous media such as those employed for good mycelium growth and biomass accumulation.
- Statins, like lovastatin and mevastatin were first isolated from different strains of fungi.
- Lovastatin was subsequently synthesized and made into the first of the statin cholesterol-lowering drugs, Mevacor.
- RESULTS: In the two patient groups, 66% of patients treated with lovastatin and 54% of patients treated with niacin underwent full dosage titration.
- Therefore, these results demonstrate that lovastatin may prove useful in the treatment of Neurofibromatosis Type 1.
- Results: Of the 60 patients, only 44 were available for efficacy analysis, 18 in gemfibrozil group and 26 in lovastatin group and the rest were drop outs.
- Active liver disease or unexplained transaminase elevations are contraindications to the use of lovastatin.
- A postmarketing surveillance study 7 reported on 48 cases with known outcome of women using lovastatin during pregnancy.
- The present study was undertaken to compare the effects of policosanol and lovastatin on SMC proliferation in the cuffed carotid artery of rabbits.
- Eating grapefruit or drinking grapefruit juice may increase the amount of Lovastatin in your blood, which may increase your risk for serious side effects.
- Lovastatin is proven to reduce the risk of coronary artery disease events, such as heart attack or angina (chest pain).
- Some medicines increase the risk of muscle side effects while taking lovastatin.
- One of these compounds is lovastatin (Mevacor®), a prescription drug used to reduce cholesterol levels.
- Lovastatin is clinically used to treat patients with hypercholesterolemia and successfully lowers cholesterol levels.
- Women who may become pregnant should use effective birth control while taking Lovastatin.
- It is not known if Lovastatin is found in breast milk.
- It is not known whether lovastatin passes into breast milk.
- Policosanol, but not lovastatin, significantly increased (p < 0.01) levels of HDL-cholesterol (7.5%).
- Lovastatin decreases coenzyme Q levels in humans.
- Lovastatin decreases coenzyme Q levels in rats.
- The dosage of lovastatin (once daily in the evening) was 20 mg for the first 4 weeks, and 40 mg thereafter.
- The diet slightly reduced the levels of apolipoproteins A-I and A-II; both diet and lovastatin reduced apolipoprotein B levels.
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- It has been discovered that lovastatin, a kind of anticholesterol drug, has the same effect as Lorenzo’s oil without a low-fat diet (25, 26).
- Twenty-eight men with verified coronary heart disease and hypercholesterolemia received 450 IU alpha-tocopherol daily with lovastatin or with placebo.
- Nineteen men with coronary heart disease and hypercholesterolemia received lovastatin with or without ubiquinone during 6-week periods after wash-out.
- CONCLUSIONS: Lovastatin and niacin both exerted favorable dose-dependent changes on the concentrations of plasma lipids and lipoproteins.
- The empirical formula of lovastatin is C 24 H 36 O 5 and its molecular weight is 404.55.
- Eight patients received additional medical therapy including administration of Lorenzo’s oil or lovastatin.
- Medicine > Drugs > Statins > Pravastatin
- Humans > Medicine > Drugs > Fluvastatin
* Adolescent Girls
* Adverse Reactions
* Aspergillus Terreus
* Comparative Effects
* Dietary Therapy
* Evening Meal
* Grapefruit Juice
* Grundy Sm
* Heterozygous Familial Hypercholesterolemia
* Hmg-Coa Reductase
* Hmg-Coa Reductase Inhibitors
* Human Plasma
* Ldl Cholesterol
* Lipoprotein Levels
* Low-Cholesterol Diet
* Oral Ingestion
* Primary Hypercholesterolemia
* Prothrombin Time
* Statin Drugs
* Study Results
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