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  Encyclopedia of Keywords > Simvastatin > Lovastatin   Michael Charnine

Keywords and Sections
APOLIPOPROTEIN
SAFETY PROFILE
SUBMERGED CULTURE
POLYKETIDE CHAINS
LOW-DOSE LOVASTATIN
LOVASTATIN CONTENT
RED YEAST RICE
HUMAN PLASMA PROTEINS
EXTENDED-RELEASE NIACIN
ADVICOR
FIBRATES
MONACOLIN
MEVASTATIN
LESTRIC
LOVASTATIN GROUP
LOVASTATIN TABLETS
LOVASTATIN THERAPY
INHIBITION
VITRO
PRESCRIPTION DRUG
TYPE
CHANGES
TRANSIENT
LDL-C
LOWERING
MYCELIUM
DOCTOR
STRAINS
FIRST
RESULTS
CONTRAINDICATIONS
PREGNANCY
RABBITS
RISK
CHOLESTEROL LEVELS
PREGNANT
BREAST MILK
LEVELS
DOSAGE
DIET
PRESCRIPTION
LOW-FAT DIET
CORONARY HEART DISEASE
LIPOPROTEINS
MOLECULAR WEIGHT
ADMINISTRATION
Review of Short Phrases and Links

    This Review contains major "Lovastatin"- related terms, short phrases and links grouped together in the form of Encyclopedia article.

Definitions

  1. Lovastatin is a lactone which is readily hydrolyzed in vivo to the corresponding (beta)-hydroxyacid, a potent inhibitor of HMG-CoA reductase.
  2. Lovastatin is a cholesterol-lowering medication that blocks the production of cholesterol (a type of fat) in the body.
  3. Lovastatin is a cholesterol lowering agent isolated from a strain of Aspergillus terreus.
  4. Lovastatin is a specific inhibitor of HMG-CoA reductase, the enzyme which catalyzes the conversion of HMG-CoA to mevalonate.
  5. Lovastatin is a naturally occurring drug found in food such as oyster mushrooms[ 1] and red yeast rice[ 2].

Apolipoprotein

  1. Apolipoprotein B concentration falls substantially during treatment with lovastatin.

Safety Profile

  1. Estrogen-replacement therapy appeared to have no effect on either the efficacy or safety profile of lovastatin.

Submerged Culture

  1. Later, the presence of lovastatin was detected in a submerged culture of three higher Basidiomycetes species: Pleurotus ostreatus, P. saca and P. sapidus.

Polyketide Chains

  1. Lovastatin is comprised of 2 polyketide chains derived from acetate that are 8- and 4- carbons long coupled in head to tail fashion.

Low-Dose Lovastatin

  1. Low-dose lovastatin safely lowers cholesterol after cardiac transplantation.

Lovastatin Content

  1. B. Testing of lovastatin Lovastatin content in the submerged mycelium was determined according to the method described in Example 1.

Red Yeast Rice

  1. Researchers aren't sure if the cholesterol-lowering effect of red yeast rice was due to the presence of lovastatin or other compounds in red yeast rice.

Human Plasma Proteins

  1. Both lovastatin and its b-hydroxyacid metabolite are highly bound (95%) to human plasma proteins.
  2. Both lovastatin and its (beta)-hydroxyacid metabolite are highly bound (95%) to human plasma proteins.

Extended-Release Niacin

  1. Efficacy of extended-release niacin with lovastatin for hypercholesterolemia: assessing all reasonable doses with innovative surface graph analysis.

Advicor

  1. Advicor is a combination product containing both extended-release niacin and lovastatin (Mevacor).

Fibrates

  1. Therefore, the combined use of lovastatin with other fibrates should generally be avoided.

Monacolin

  1. Rice fermented with red yeast contains several types of mevinic acids, including monacolin K, which is identical to lovastatin.
  2. Cholestin is an extract from RYR containing a special strain of yeast which produces monacolin K (lovastatin) [ 7].

Mevastatin

  1. The structure of Lovastatin was determined to be different from that of mevastatin by the presence of a 6 alphamethyl group in the hexahydronaphthalene ring.

Lestric

  1. All actions at purchase Mevacor, Lestric, Lovastatin are executed with our safe operational server.

Lovastatin Group

  1. The frequency of patients reporting improvement on quality of life domains was greater in the policosanol than in the lovastatin group.
  2. After eight weeks of therapy, LDL-cholesterol was reduced 24% in the policosanol groups, 22% in the lovastatin group and 15% with simvastatin.
  3. In the lovastatin group there was a significant reduction in the number of patients with major cardiovascular events relative to the placebo group (5 vs.

Lovastatin Tablets

  1. Although lovastatin tablets 10 mg are available in the marketplace, MEVACOR is no longer marketed in the 10 mg strength.
  2. Take lovastatin tablets by mouth.

Lovastatin Therapy

  1. The long-term efficacy of lovastatin therapy in childhood to reduce morbidity and mortality in adulthood has not been established.
  2. Lovastatin therapy should be discontinued immediately if myopathy is diagnosed or suspected.
  3. Not all the effects listed below have necessarily been associated with lovastatin therapy.

Inhibition

  1. The increase in AUC for lovastatin and lovastatin acid is presumably due, in part, to inhibition of CYP3A4.

Vitro

  1. We conclude that lovastatin can induce apoptosis in BPH stromal cells in vitro, and this is not affected by androgen withdrawal or stimulation.

Prescription Drug

  1. One of these, monacolin K, has the same chemical makeup as lovastatin, a prescription drug that lowers cholesterol.

Type

  1. Comparative efficacy study of atorvastatin vs simvastatin, pravastatin, lovastatin and placebo in type 2 diabetic patients with hypercholesterolaemia.

Changes

  1. Lovastatin reduces cholesterol production by the liver and induces some changes in cholesterol transport and disposition in the blood and tissues.
  2. Changes in ICD and ACD were significantly larger in the policosanol than in the lovastatin group (p < 0.01).

Transient

  1. Transient, mildly elevated creatine phosphokinase levels are commonly seen in lovastatin treated patients.

Ldl-C

  1. In large, comparative trials atorvastatin produced greater reductions in TC, LDL-C, apo B, and TGs than lovastatin, pravastatin, or simvastatin.

Lowering

  1. Consequently, lovastatin therapy could also result in a lowering of cellular CoQ levels.

Mycelium

  1. No lovastatin was detected in the culture broth filtrate samples after separation from the mycelium.
  2. B. Testing of lovastatin The incubated broth was filtered through a filter cloth to remove the mycelium and washed twice with distilled water.

Doctor

  1. Tell your doctor or dentist that you take Lovastatin before you receive any medical or dental care, emergency care, or surgery.
  2. Check with your doctor before drinking alcohol while you are taking Lovastatin.

Strains

  1. The culture of these strains to produce lovastatin is carried out in aqueous media such as those employed for good mycelium growth and biomass accumulation.

First

  1. Statins, like lovastatin and mevastatin were first isolated from different strains of fungi.
  2. Lovastatin was subsequently synthesized and made into the first of the statin cholesterol-lowering drugs, Mevacor.

Results

  1. RESULTS: In the two patient groups, 66% of patients treated with lovastatin and 54% of patients treated with niacin underwent full dosage titration.
  2. Therefore, these results demonstrate that lovastatin may prove useful in the treatment of Neurofibromatosis Type 1.
  3. Results: Of the 60 patients, only 44 were available for efficacy analysis, 18 in gemfibrozil group and 26 in lovastatin group and the rest were drop outs.

Contraindications

  1. Active liver disease or unexplained transaminase elevations are contraindications to the use of lovastatin.

Pregnancy

  1. A postmarketing surveillance study 7 reported on 48 cases with known outcome of women using lovastatin during pregnancy.

Rabbits

  1. The present study was undertaken to compare the effects of policosanol and lovastatin on SMC proliferation in the cuffed carotid artery of rabbits.

Risk

  1. Eating grapefruit or drinking grapefruit juice may increase the amount of Lovastatin in your blood, which may increase your risk for serious side effects.
  2. Lovastatin is proven to reduce the risk of coronary artery disease events, such as heart attack or angina (chest pain).
  3. Some medicines increase the risk of muscle side effects while taking lovastatin.

Cholesterol Levels

  1. One of these compounds is lovastatin (Mevacor®), a prescription drug used to reduce cholesterol levels.
  2. Lovastatin is clinically used to treat patients with hypercholesterolemia and successfully lowers cholesterol levels.

Pregnant

  1. Women who may become pregnant should use effective birth control while taking Lovastatin.

Breast Milk

  1. It is not known if Lovastatin is found in breast milk.
  2. It is not known whether lovastatin passes into breast milk.

Levels

  1. Policosanol, but not lovastatin, significantly increased (p < 0.01) levels of HDL-cholesterol (7.5%).
  2. Lovastatin decreases coenzyme Q levels in humans.
  3. Lovastatin decreases coenzyme Q levels in rats.

Dosage

  1. The dosage of lovastatin (once daily in the evening) was 20 mg for the first 4 weeks, and 40 mg thereafter.

Diet

  1. The diet slightly reduced the levels of apolipoproteins A-I and A-II; both diet and lovastatin reduced apolipoprotein B levels.

Prescription

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Low-Fat Diet

  1. It has been discovered that lovastatin, a kind of anticholesterol drug, has the same effect as Lorenzo’s oil without a low-fat diet (25, 26).

Coronary Heart Disease

  1. Twenty-eight men with verified coronary heart disease and hypercholesterolemia received 450 IU alpha-tocopherol daily with lovastatin or with placebo.
  2. Nineteen men with coronary heart disease and hypercholesterolemia received lovastatin with or without ubiquinone during 6-week periods after wash-out.

Lipoproteins

  1. CONCLUSIONS: Lovastatin and niacin both exerted favorable dose-dependent changes on the concentrations of plasma lipids and lipoproteins.

Molecular Weight

  1. The empirical formula of lovastatin is C 24 H 36 O 5 and its molecular weight is 404.55.

Administration

  1. Eight patients received additional medical therapy including administration of Lorenzo’s oil or lovastatin.

Categories

  1. Simvastatin
  2. Policosanol
  3. Atorvastatin
  4. Medicine > Drugs > Statins > Pravastatin
  5. Humans > Medicine > Drugs > Fluvastatin

Related Keywords

    * Additive * Adolescent Girls * Adverse Reactions * Age * Aspergillus Terreus * Atorvastatin * Breast-Feeding * Cerivastatin * Cholesterol * Cholestyramine * Clinical * Comparative Effects * Dietary Therapy * Dose * Drug * Drugs * Effect * Effects * Efficacy * Erythromycin * Evening Meal * Ezetimibe * Fda * Fluvastatin * Food * Gemfibrozil * Grapefruit Juice * Grundy Sm * Health * Heterozygous Familial Hypercholesterolemia * Hmg-Coa Reductase * Hmg-Coa Reductase Inhibitors * Human Plasma * Hypercholesterolemia * Ldl * Ldl Cholesterol * Lipoprotein Levels * Low-Cholesterol Diet * Metabolites * Mevacor * Mevalonate * Niacin * Oral Ingestion * Patient * Patients * Pharmacokinetics * Placebo * Policosanol * Pravastatin * Prescriber * Primary Hypercholesterolemia * Probucol * Propranolol * Prothrombin Time * Randomized * Safety * Simvastatin * Statin * Statins * Statin Drugs * Studies * Study * Study Results * Therapy * Tolerability * Treatment * Triglycerides
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  Originally created: June 28, 2007.
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