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  Encyclopedia of Keywords > Notochord > Shh   Michael Charnine

Keywords and Sections
FUNCTIONS
NATURE
WHETHER
MOUSE EMBRYOS
NEURONAL DIFFERENTIATION
SHH PATHWAY
MARTI ET
KALYANI ET
UNDERLYING NOTOCHORD
CULTURED PSM
VERTEBRATE HOMOLOG
MARIGO ET
OPCS
VENTRALIZING
ERICSON ET
GLI3
SHH MUTANTS
PTCH
CULTURES
CONTRAST
ESSENTIAL
DATA
CHOLESTEROL
ADDITION
TARGET
ACT
ARROW
MOUSE
REQUIRED
MAINTENANCE
FACTORS
FORMATION
RESULTS
RECEPTOR
MUTATIONS
WILD-TYPE
IMPORTANT
SUGGESTING
EFFECTS
NEURONS
GENE
VITRO
ACTIVATION
REGULATING
ROLE
DEVELOPMENT
Review of Short Phrases and Links

    This Review contains major "Shh"- related terms, short phrases and links grouped together in the form of Encyclopedia article.

Definitions

  1. SHH is the major gene implicated in HPE and it plays a critical role in early forebrain and central nervous system development.
  2. SHH is the major gene implicated in holoprosencephaly (12.7% of HPE cases: 50% of overall point mutations and 38% of overall large deletions) [ 50, 51]. (Web site)
  3. Shh is the most extensively characterized vertebrate homolog, and is involved in morphogenesis of several organs including the eye, hair and lungs. (Web site)
  4. SHH is expressed in the human embryo in the notochord, the floorplate of the neural tube, and the posterior limb buds. (Web site)
  5. SHH was initially described as a protein secreted from two signalling centres, the notochord and the floor plate.

Functions

  1. Name two functions of sonic hedgehog (SHH). ------ It is produced by the notochord and it: 1.

Nature

  1. One can ask how Gli proteins act and what the nature of Shh signaling during CNS dorsal-ventral patterning is. (Web site)

Whether

  1. What is not known is whether this phenotype is completely independent of Shh signaling. (Web site)

Mouse Embryos

  1. Runx2 (Cbfa1) inhibits Shh signaling in the lower but not upper molars of mouse embryos and prevents the budding of putative successional teeth. (Web site)

Neuronal Differentiation

  1. Shh stimulated neuronal differentiation; however, it did not increase the proportion of neurons expressing the first postmitotic motoneuron marker Islet-1. (Web site)

Shh Pathway

  1. In some embodiments of either aspect, the activator of the SHH pathway is SHH or purmorphamine. (Web site)

Marti Et

  1. S, Distribution of Shh protein demonstrated by immunostaining with anti-Shh serum (Marti et al., 1995a).

Kalyani Et

  1. A second possibility was that Shh actually inhibited the differentiation of Isl-1 motor neurons, as suggested from in vitro studies (Kalyani et al., 1998).

Underlying Notochord

  1. The underlying notochord produces the well-known transcription factor, Sonic hedgehog ("Shh") [5].

Cultured Psm

  1. In the absence of Shh, BMP administration induces lateral plate gene expression in cultured psm. (Web site)

Vertebrate Homolog

  1. PTC, a vertebrate homolog of this Drosophila gene, is genetically downstream of Sonic hedgehog (Shh) in the limb bud.

Marigo Et

  1. Sonic hedgehog (Shh) up-regulates Gli1 transcription but down-regulates Gli3 expression (Marigo et al. (Web site)

Opcs

  1. Therefore, the differentiation of OPCs was strictly dependent upon SHH. (Web site)
  2. These Olig2 progenitors no longer produced motor neurons, but instead generated OPCs after eight additional weeks of SHH treatment. (Web site)

Ventralizing

  1. Tiarin directly dorsalizes neural tissues in the absence of mesodermal tissues and antagonizes the ventralizing activity of Sonic hedghog (Shh). (Web site)

Ericson Et

  1. The exact pattern of marker gene expression and eventual cell fate is thought to depend on the concentration of Shh (Ericson et al. (Web site)

Gli3

  1. Coexpression of c-Ski with Shh and Gli3 significantly lowered the level of induction of Gli1 mRNA by about 3.8-fold. (Web site)

Shh Mutants

  1. Like Shh mutants and Gli2 mutants (Chiang et al. (Web site)
  2. We found that the abrogation of Ptch expression exhibited by Shh mutants is indeed partially alleviated by loss of Tectonic function (Fig. (Web site)

Ptch

  1. They could subsequently enhance the repressive activity of PTCH on the SHH pathway and so decrease SHH signaling. (Web site)

Cultures

  1. At day 35, OLIG2 and NKX2.2 co-express only in cultures with SHH or purmorphamine. (Web site)

Contrast

  1. In contrast to Gli1 and Gli2, there is little doubt that Gli3 acts as a repressor of Hh targets as well as of Shh itself (Masuya et al. (Web site)

Essential

  1. However, Shh signaling is not essential for differentiation of ameloblasts or odontoblasts. (Web site)

Data

  1. However, in preliminary electroporation experiments using activators of the Wnt pathway we never observed downregulation of Shh in the ZLI (data not shown).

Cholesterol

  1. Lanosterol synthase catalyzes a key step in the biosynthesis of cholesterol, essential in the maturation of the SHH protein. (Web site)

Addition

  1. In addition, there is evidence that Shh signaling may specify oligodendrocyte precursors (Poncet et al., 1996; Pringle et al., 1996).
  2. In addition to identifying expected Gli-target sites, the data predicted a number of unreported direct targets of Shh action.

Target

  1. In addition, Gli3 is itself a target of transcriptional repression by Shh (Marigo et al. (Web site)

Act

  1. Shh cannot act alone to induce a floor plate. (Web site)

Arrow

  1. I, L, Expression of HES-1 was upregulated in Shh -Tg (arrow) in cells lining the VZ. J, M, Pax-6 was maintained in a similar pattern of expression (arrow).

Mouse

  1. First, we used Shh as a molecular marker to establish a precise temporal sequence for rugae appearance in mouse.

Required

  1. SIL is a cytosolic protein required in mouse for left-right axis development and Shh signaling (Izraeli et al., 2001; Izraeli et al., 1999).

Maintenance

  1. These results point out that not all the midbrain neuronal populations are dependent on Shh for their maintenance, as previously thought.
  2. I, J, Maintenance and expansion of roofplate cells indicated by expression of Wnt-3a in Shh -Tg tissue.

Factors

  1. In addition, some of the factors with pro-neurogenic effects (such as NT-3 and Shh) can be secreted by GABAergic interneurons [62].

Formation

  1. That is, we cannot with certainty establish a cause-effect relationship between the absence of Shh expression and the formation of the rosettes. (Web site)

Results

  1. The floor plate then produces its own SHH which results in motor neurons developing on either side.
  2. These results suggest that the neural tube angiogenesis is dependent on Shh signaling, and mediated, at least in part, by the Ang-1 positive motor neurons.
  3. These results confirmed that the oligodendrocyte lineage was induced in the hyperplastic tissue surrounding the VZ in Shh -Tg mice.

Receptor

  1. PATCHED-1 (PTCH) is the receptor for SHH, and normally acts to repress SHH signaling. (Web site)

Mutations

  1. Growing evidence suggests that the disorder may result from mutations in genes of the Sonic hedgehog (Shh) signalling pathway. (Web site)
  2. These patterning defects are qualitatively similar to those caused by mutations in Shh or Gli2 (Chiang et al. (Web site)

Wild-Type

  1. Q, R, Wild-type and Shh -Tg cervical spinal cord tissues showing expression of Shh.

Important

  1. SHH remains important in the adult. (Web site)

Suggesting

  1. Moreover, Shh did induce Islet-1 expression in neural tube explants, suggesting that it acts in combination with neural tube factors to induce motoneurons. (Web site)

Effects

  1. Shh mediates its effects by binding to its receptor, Patched (Ptch). (Web site)

Neurons

  1. This is a dynamic process in which increasing concentrations and durations of exposure to SHH generate neurons with successively more ventral identities. (Web site)

Gene

  1. In the present study we performed mutational analysis of the entire coding region of the SHH gene in 37 unrelated individuals with the HPE spectrum.
  2. The sonic hedgehog (Shh) gene has been identified in defects that cause hydrocephalus secondary to holoprosencephaly. (Web site)

Vitro

  1. In vitro, the inductive properties of the notochord are mimicked by Shh (Fan et al. (Web site)

Activation

  1. The hypothesised mechanism suggests that Shh binds patched, relieving patched inhibition of smoothened, leading to activation of glia transcription factors.

Regulating

  1. The determination of diverse cell fates by Shh signaling occurs by regulating the combination of Gli genes expressed in a cell. (Web site)

Role

  1. In addition to its role in ventral neural tube patterning, SHH participates in the control of progenitor cell number in developing dorsal brain.
  2. These results suggest that Shh may play a role in the normal inductive interactions that pattern the ventral CNS.
  3. Incardona JP, Roelink H: The role of cholesterol in Shh signaling and teratogen-induced holoprosencephaly.

Development

  1. Here, for the first time, we analyze in detail the development of the different mesencephalic basal nuclei in the absence of Shh. (Web site)

Categories

  1. Notochord
  2. Bmp
  3. Encyclopedia of Keywords > Information > Structure > Neural Tube
  4. Expression
  5. Differentiation

Related Keywords

    * Absence * Bmp * Bmp Signaling * Cells * Cell Types * Cns * Concentration-Dependent Manner * Differentiation * Ectopic Expression * Explants * Expression * Fig * Floorplate * Floor Plate * Forebrain * Function * Hedgehog * Hpe * Induction * Morphogenesis * Motor Neurons * Neural Tube * Noggin * Notochord * Repression * Sclerotome * Secreted * Shh -Tg Mice * Shh Signaling * Signaling * Signaling Molecule * Signal Transduction * Smo * Sonic Hedgehog * Spinal Cord * Time * Ventral * Ventral Neural Tube * Vivo
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  Short phrases about "Shh"
  Originally created: April 04, 2011.
  Links checked: April 16, 2013.
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