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  Encyclopedia of Keywords > Shh > Sonic Hedgehog   Michael Charnine

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    This Review contains major "Sonic Hedgehog"- related terms, short phrases and links grouped together in the form of Encyclopedia article.


  1. Sonic hedgehog (SHH) is a member of the hedgehog family of signalling molecules.
  2. Sonic Hedgehog is a secreted morphogen involved in patterning a wide range of structures in the developing embryo.
  3. Sonic hedgehog (Shh) is a key signal in the specification of ventral cell identities along the length of the developing vertebrate neural tube. (Web site)
  4. Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity.
  5. Sonic Hedgehog (SHH) is the morphogenetic signal produced by the polarizing region in the posterior limb bud.

Limb Bud

  1. PTC, a vertebrate homolog of this Drosophila gene, is genetically downstream of Sonic hedgehog (Shh) in the limb bud.

Signal Transduction

  1. Gli2 and Gli3 in a developing hindbrain also have distinct functions in the Shh (sonic hedgehog) signal transduction.

Developmental Biology

  1. Named after a character in a video game, Sonic hedgehog is a favorite in developmental biology.


  1. The secreted protein encoded by the Sonic hedgehog (Shh) gene is expressed by axial midline cells and can induce floor plate cells in vivo and in vitro.

Nerve Function

  1. They showed that treatment with the Sonic Hedgehog protein restored nerve function to normal in pre-clinical models of diabetic neuropathy.


  1. Involvement of Sonic hedgehog (Shh) in mouse embryonic lung growth and morphogenesis. (Web site)

Neural Tube

  1. Sonic hedgehog induces the differentiation of ventral forebrain neurons: a common signal for ventral patterning within the neural tube.
  2. As in the limb bud, ectopic expression of Sonic hedgehog leads to ectopic induction of PTC in the neural tube and paraxial mesoderm.

Motor Neurons

  1. Motor neurons can also be induced in vitro by cells that synthesize Sonic hedgehog protein (Shh).
  2. In the central nervous system, Sonic hedgehog has been identified as the signal inducing floor plate, motor neurons, and dopaminergic neurons.


  1. In contrast, Sonic hedgehog (Shh) suppresses differentiation of neural crest lineages and promotes that of ventral CNS tissues such as motor neurons. (Web site)
  2. The ventral spinal cord is specified through a concentration gradient of Sonic hedgehog (Shh) protein secreted by the notochord.
  3. However, there is a progressive loss of early, Sonic hedgehog (Shh)-dependent ventral cell fates despite the normal expression of Shh in the notochord. (Web site)

Sonic Hedgehog

  1. The Sonic hedgehog (Shh) signaling molecule assumes various roles in patterning the central nervous system (CNS) during vertebrate development. (Web site)
  2. In the first of these, high concentrations of Sonic hedgehog (Shh) produced by the notochord induce the floor plate at the ventral midline. (Web site)
  3. During development, dorsoventral patterning along the neural tube is controlled by the expression of sonic hedgehog (shh) [ 42].


  1. Shh
  2. Notochord
  3. Floor Plate
  4. Patterning
  5. Ptc
  6. Books about "Sonic Hedgehog" in

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  Short phrases about "Sonic Hedgehog"
  Originally created: February 05, 2007.
  Links checked: May 04, 2013.
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